MicroRNAs及其在肝病中的研究进展
| 作 者：虢灿杰, 潘勤, 李定国 |
| 单 位：上海交通大学医学院附属新华医院 |
| 基金项目：上海市科委基础研究重点项目基金资助(O7JC14044） |
| 摘 要： |
| 微小RNA （miRNAs）是近年发现的一种以序列特异性方式转录后调控基因表达的非编码单链小分子RNA（small RNA），长度为21～25核苷酸 (nucleotide, nt)。miRNAs通过与靶基因mRNA的3’非编码区（3’UTRs）以完全互补或不完全互补方式结合调节靶基因的表达。miRNAs参与多种生物学调控过程，对疾病的诊断和防治具有重要意义。本文就miRNAs的生物发生、作用机制及其在肝病中的研究进展作一综述。 |
| 关键词：微RNAs；脂肪肝；肝肿瘤 |
Research Progression of microRNAs and its Role in Liver Diseases
| Author's Name: |
| Institution: |
| Abstract: |
| miRNAs is a recently discovered family of small non-protein-coding RNA with 21-25nt, which regulate gene expression in a sequence-specific manner at post-transcriptional level through incomplete or complete complementary binding to 3’UTRs of the target gene. miRNAs have been implicated in a variety of biological processes, which are considered to be particularly important in diagnosis and treatment of diseases. This paper reviewed the biogenesis, mechanism of action of miRNAs and its role in liver diseases. |
| Keywords: MicroRNAs; Fatty Liver; Liver Neoplasma |
| 投稿时间：2009-05-24 |
|
|
|
查看pdf文件
|
|
