IL-18与幽门螺杆菌感染的关系及其致病作用研究进展
| 作 者：吴文朝, 徐雷鸣 |
| 单 位：上海交通大学医学院附属新华医院 |
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| 摘 要： |
| 白细胞介素-18（IL-18）是一种重要的细胞免疫调节因子，幽门螺杆菌（H. pylori）能促进胃上皮细胞和黏膜固有层单核细胞分泌IL-18，参与包括慢性胃炎、消化性溃疡、胃癌和胃黏膜相关淋巴组织（MALT）淋巴瘤等多种胃十二指肠疾病的发生。本文就IL-18与H. pylori 感染的关系及其致病作用研究进展作一综述。 |
| 关键词：白细胞介素18；螺杆菌，幽门；胃肠疾病 |
Advances in Study of Relationship between IL-18 and Helicobacter pylori Infection and its Pathogenic Effect
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| Abstract: |
| Interleukin-18 (IL-18) is an important regulatory factor of cellular immunity, Helicobacter pylori (H. pylori) can promote the secretion of IL-18 by gastric mucosa epithelial cells and lamina propria mononuclear cells, and IL-18 is involved in the development of many gastroduodenal diseases including chronic gastritis, peptic ulcer, gastric cancer and gastric mucosa-associated lymphoid tissue (MALT) lymphoma. This article reviewed the advances in study of relationship between IL-18 and H. pylori infection and its pathogenic effect. |
| Keywords: Interleukin-18; Helicobacter pylori; Gastrointestinal Diseases |
| 投稿时间：2009-05-27 |
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