高胰岛素血症与结直肠腺瘤的相关性及其可能机制
| 作 者：周素雅, 郭鹤鸣, 沈颖筱, 周菲菲, 余强 |
| 单 位：南京医科大学附属苏州医院 |
| 基金项目：2023年度吴中区科技计划项目 |
| 摘 要： |
| 胰岛素抵抗作为代谢综合征的重要组分之一，与多种疾病的发生、发展相关。机体发生胰岛素抵抗时，为维持血糖稳态，会代偿性地增加胰岛素分泌，导致代偿性高胰岛素血症。近年研究发现，高胰岛素血症与结直肠腺瘤发生率升高之间存在显著相关性，是结直肠腺瘤的独立危险因素之一，两者可能存在共同的发病机制。本文就高胰岛素血症与结直肠腺瘤的相关性、以及两者可能的共同发病机制作一综述，提出该领域的未解科学问题并作出推测，展望预防高胰岛素血症对降低结直肠腺瘤发生风险的作用。 |
| 关键词：高胰岛素血症；胰岛素抵抗；结直肠腺瘤；结直肠肿瘤 |
Correlation and Possible Mechanisms Between Hyperinsulinemia and Colorectal Adenoma
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| Abstract: |
| Insulin resistance, as a key component of metabolic syndrome, is associated with the occurrence and progression of various diseases. Under insulin-resistant conditions, the body compensatorily increases insulin secretion to maintain blood glucose homeostasis, leading to compensatory hyperinsulinemia. Recent studies have demonstrated that hyperinsulinemia is significantly correlated with an increased incidence of colorectal adenoma and serves as one of its independent risk factors, suggesting that the two conditions may share common pathogenic mechanisms. This article reviewed the association between hyperinsulinemia and colorectal adenoma, as well as their potential common pathogenic mechanisms. Furthermore, unresolved scientific questions in this field were proposed and postulated, and the potential role of preventing hyperinsulinemia in reducing the risk of colorectal adenoma was explored prospectively. |
| Keywords: Hyperinsulinemia; Insulin Resistance; Colorectal Adenomas; Colorectal Neoplasms |
| 投稿时间：2025-09-02 |
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