外泌体和热休克蛋白在炎症性肠病中的研究进展
| 作 者：万宇红, 白欣宇, 缪应雷 |
| 单 位：昆明医科大学 |
| 基金项目：国家自然科学基金；云南省教育厅科学研究基金项目；昆明医科大学研究生教育创新基金项目 |
| 摘 要： |
| 炎症性肠病（IBD）包括克罗恩病和溃疡性结肠炎，其病因尚未完全明确，发病机制与宿主-微生物之间的动态平衡密切相关。外泌体是由多种细胞释放的囊泡状结构，可携带蛋白质、脂质、核酸等生物活性成分，参与细胞间通讯。热休克蛋白（HSP）是一类高度保守的蛋白质，在IBD的诊断、治疗、预后评估中具有重要作用。本文就外泌体、HSP与IBD三者之间的关联作一系统阐述，并探讨外泌体和HSP在IBD进展中的作用机制，以及外泌体作为新型药物载体在IBD治疗中的应用前景。 |
| 关键词：炎症性肠病；外泌体；热休克蛋白 |
Research Progress on Exosomes and Heat Shock Proteins in Inflammatory Bowel Disease
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| Abstract: |
| Inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis, has an unclear etiology, and its pathogenesis is closely associated with the dynamic homeostasis between the host and microbiota. Exosomes are vesicular structures released by various cells, carrying bioactive components such as proteins, lipids, and nucleic acids, and are involved in intercellular communication. Heat shock proteins (HSPs) are a family of highly conserved proteins that play important roles in the diagnosis, treatment, and prognosis assessment of IBD. This article systematically reviewed the relationship among exosomes, HSPs, and IBD, and explored the mechanisms of exosomes and HSPs in the progression of IBD, as well as the prospects of exosomes as novel drug delivery vehicles in the treatment of IBD. |
| Keywords: Inflammatory Bowel Disease; Exosomes; Heat Shock Proteins |
| 投稿时间：2025-10-09 |
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