基于肠-脑轴的经皮耳迷走神经刺激治疗消化系统疾病的应用和展望
| 作 者：李毓玲, 左国文, 钟丽坤 |
| 单 位：广西壮族自治区人民医院 |
| 基金项目：广西自然科学基金；广西医疗卫生适宜技术开发与推广应用项目 |
| 摘 要： |
| 经皮耳迷走神经刺激（taVNS）是一种安全、低成本、非侵入性的迷走神经调控技术，通过刺激耳部迷走神经调控肠-脑轴，在消化系统疾病治疗领域中展现出较好的临床应用前景。taVNS在消化系统疾病中发挥多维治疗机制，包括调节自主神经平衡、激活胆碱能抗炎通路以及调控镇痛通路，三者通过肠-脑轴交互协同，共同构成了多维调控网络。现有研究表明，taVNS对多种消化系统疾病，特别是功能性胃肠病具有改善症状的潜力，有望成为一种辅助或补充治疗策略。本文就基于肠-脑轴的taVNS治疗消化系统疾病的应用和展望作一综述，系统阐述taVNS在消化系统疾病中的机制研究进展和临床应用前景，为其临床转化提供理论依据。 |
| 关键词：经皮耳迷走神经刺激；消化系统疾病；肠-脑轴；神经调节 |
Transcutaneous Auricular Vagus Nerve Stimulation Based on Gut-brain Axis for Digestive System Diseases: Applications and Perspectives
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| Abstract: |
| Transcutaneous auricular vagus nerve stimulation (taVNS) is a safe, low‑cost, and non‑invasive neuromodulation technique that regulates the gut‑brain axis through stimulation of the auricular branch of the vagus nerve, showing promising clinical application prospects in the treatment of digestive system diseases. taVNS exerts multidimensional therapeutic mechanisms in digestive system diseases, including regulation of autonomic balance, activation of the cholinergic anti‑inflammatory pathway, and modulation of analgesic pathway. These three mechanisms interact and synergize via the gut-brain axis, collectively forming a multidimensional regulatory network. Current studies suggest that taVNS has the potential to improve symptoms in a variety of digestive system diseases, particularly functional gastrointestinal disorders, and may serve as an adjunctive or complementary therapeutic strategy. This article reviewed the application and perspectives of taVNS in digestive system diseases based on the gut-brain axis, the mechanistic research progress and clinical application prospects of taVNS in these conditions were systematically elaborated, aiming to offer a theoretical foundation for its clinical translation. |
| Keywords: Transcutaneous Auricular Vagus Nerve Stimulation; Digestive System Diseases; Gut-Brain Axis; Neuromodulation |
| 投稿时间：2025-12-07 |
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