PPARγ在溃疡性结肠炎中作用机制的研究进展
| 作 者：王婧, 高鸿亮 |
| 单 位：新疆医科大学第一附属医院消化病二科 |
| 基金项目：国家自然科学基金地区科学基金项目；新疆维吾尔自治区重点研发计划项目；新疆维吾尔自治区“天山英才”医药卫生高层次人才培养计划中青年骨干医疗人才；新疆维吾尔自治区卫生健康青年医学科技人才专项 |
| 摘 要： |
| 溃疡性结肠炎（UC）是一种慢性非特异性肠道炎症性疾病，其复杂发病机制，尚未完全阐明。近年来，过氧化物酶体增殖物激活受体γ（PPARγ）在维持肠道稳态中的作用日益受到关注。该核转录因子通过多重机制参与UC进程，在调节肠黏膜屏障功能、抑制肠道炎症、调控免疫反应、抑制病理性纤维化以及维持菌群稳态中发挥重要作用。本文系统阐述PPARγ在UC中的多重保护机制，以期为UC的临床治疗提供新的理论依据和策略。 |
| 关键词：结肠炎，溃疡性；过氧化物酶体增殖物激活受体γ；黏膜屏障；炎症反应 |
Research Progress on Mechanisms of PPARγ in Ulcerative Colitis
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| Abstract: |
| Ulcerative colitis (UC) is a chronic non-specific inflammatory bowel disease, the complex pathogenesis of which has not been fully elucidated. In recent years, the role of peroxisome-proliferator-activated receptor γ (PPARγ) in maintaining intestinal homeostasis has gained increasing attention. This nuclear transcription factor participates in the progression of UC through multiple mechanisms, playing important roles in regulating intestinal mucosal barrier function, suppressing intestinal inflammation, modulating immune responses, preventing pathological fibrosis, and maintaining microbial homeostasis. This article systematically elaborated the multifaceted protective mechanisms of PPARγ in UC, aiming to provide new theoretical foundations and therapeutic strategies for the clinical management of UC. |
| Keywords: Colitis, Ulcerative; Peroxisome-Proliferator-Activated Receptor gamma; Mucosal Barrier; Inflammatory Response |
| 投稿时间：2026-02-28 |
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